Enhanced DNA Delivery Using Protein G Domains

G and G Delivery

G and g delivery relies on the tandemly linked 122-aa IgG binding domains of protein G (24) from Streptomyces to efficiently bind and deliver DNA-packaged antigens into cells that express the receptor (Fig. 4A). Hex G and pre-F/G mRNA antigen chimeras elicited comparable neutralizing antibody responses and superior NiV-specific Tfh and effector T cell response compared to G alone.

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